6/23/2023 0 Comments Non cyclic amp molecule![]() ![]() 2017 22:1027–44.Īlves H, Dechering K, Van Blitterswijk C, De Boer J. Harnessing cAMP signaling in musculoskeletal regenerative engineering. Ifegwu OC, Awale G, Rajpura K, Lo KW, Laurencin CT. The small molecule phenamil induces osteoblast differentiation and mineralization. Park KW, Waki H, Kim WK, Davies BS, Young SG, Parhami F, et al. Orthopedic tissue regeneration: cells, scaffolds, and small molecules. Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts). Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules. ![]() Combined angiogenic and osteogenic factor delivery for bone regenerative engineering. The Quest toward limb regeneration: a regenerative engineering approach. Regenerative engineering: approaches to limb regeneration and other grand challenges. Autogenous bone graft: basic science and clinical implications. Bone grafts and bone graft substitutes in orthopaedic trauma surgery. 2002 84-A:454–64.ĭe Long WG Jr, Einhorn TA, Koval K, McKee M, Smith W, Sanders R, et al. Bone-grafting and bone-graft substitutes. Use of bone graft substitutes and bioactive materials in treatment of distal radius fractures. Osteotropic nanoscale drug delivery systems based on small molecule bone-targeting moieties. 2014 10:1691–9.Ĭarbone EJ, Rajpura K, Allen BN, Cheng E, Ulery BD, Lo KW. Small molecule delivery through nanofibrous scaffolds for musculoskeletal regenerative engineering. Engineered bone tissue with naturally-derived small molecules. Studies of bone morphogenetic protein based surgical repair. Lo KW-H, Ulery BD, Ashe KM, Laurencin CT. Recent Patents on Biomedical Engineering. Current Patents on Osteoinductive Molecules for Bone Tissue Engineering. Lo KW, Ulery BD, Deng M, Ashe KM, Laurencin CT. Delivery of small molecules for bone regenerative engineering: preclinical studies and potential clinical applications. Laurencin CT, Ashe KM, Henry N, Kan HM, Lo KW. ![]() Small-molecule based musculoskeletal regenerative engineering. Lo KW, Jiang T, Gagnon KA, Nelson C, Laurencin CT. The role of small molecules in the musculoskeletal regeneration. Our work may also result in novel bone graft materials that can potentially become a viable alternative to existing grafts. We would like to treat the bone defects with a small molecule-based therapeutic agent in a short-term treatment so that undesirable side effects from the therapeutics would be significantly minimized. The goal of this work is to develop a simple, inexpensive, effective, and safe method to heal bone defect. Short-term treatment using small molecule 6-Bnz-cAMP can serve as a highly promising strategy for bone regeneration while mitigating potential non-specific side effect risks associated with small molecules. Our results showed that both short-term and continuous 6-Bnz-cAMP treatments elicited osteoblastic differentiation and mineralization of osteoblast-like MC3T3-E1 cells. It is hypothesized that the proposed short-term 6-Bnz-cAMP treatment scheme would result in osteogenesis as in the case of continuous 6-Bnz-cAMP treatment. In this study, we investigate the effect of short-term 6-Bnz-cAMP treatment, i.e., 1-day treatment, as compared to continuous treatment, on in vitro osteogenesis in osteoprogenitor cells. We previously demonstrated that the continuous treatment of osteoblast-like MC3T3-E1 cells with small molecule cyclic AMP analogue N 6-benzoyladenosine-3′,5′-cyclic monophosphate (6-Bnz-cAMP) was capable of inducing in vitro osteogenesis via the protein kinase A (PKA) signaling pathway. However, unknown non-specific toxicity of small molecules on non-target cells or organs due to the long-term exposure has been a concern. Small molecule-mediated bone regeneration is emerging as a promising strategy for replacing or enhancing the therapeutic protein-based growth factors. ![]()
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